RESULTS OF SURGICAL TREATMENT OF MEDULLOBLASTOMAS AT VIETNAM NATIONAL CANCER HOSPITAL
Tóm tắt
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Abstract
Objective: Evaluate the results of surgical treatment of medulloblastoma at K Hospital.
Subjects and methods: The study subjects include patients who underwent surgery and chemotherapy and radiotherapy at K Hospital from January 2019 to December 2023, with pathological result of medulloblastoma, with complete medical records and MRI scans. Excluding cases of recurrent medulloblastoma, cases that only received surgery, refused chemotherapy or radiotherapy after surgery or cases that did not receive adequate treatment regimen. The study is cross-sectional, retrospective and prospective.
Results: A total of 45 patients underwent surgery: Total or near-total tumor removal (accounting for 93.3%), partial tumor removal 3/45 (6.7%), the overall complication rate after surgery was 11.1%. Results of 5-year follow-up after postoperative chemoradiotherapy: the overall survival rate and progression-free survival rate were 54.3±11.1 and 50.8±8.5, respectively. The high-risk group had a median survival of 34.3 months, the intermediate-risk group had a median survival of 64.7 months, the difference was statistically significant with p=0.001.
Conclusion: histopathological types, molecular subgroups and risk stratification are important prognosticators, and are associated with overall and progression-free survival of MB patients
Từ khóa
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Keywords
Medulloblastomas, neurosurgery, Risk stratification of MB
Tài liệu tham khảo (References)
- Pham Thanh Tuân. Kết quả phẫu thuật u nguyên bào tuỷ tại bệnh viện hữu nghị việt đức. Tạp chí y học Việt Nam 2022, Tập 510, số 1, tr 231-235.
- Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumorsof the Central Nervous System: a summary. Neuro-Oncol. 2021;23(8):1231-1251
- Dhall G. Medulloblastoma. J Child Neurol. 2009;24(11):1418-1430
- HaqueW, Verma V, Brian Butler E, Teh BS.Prognostic role of themotherapy, radiotherapy dose, and extent of surgical resection in adult medulloblastoma. Journal of Clinical Neuroscience. 2020;76:154-160.
- MuzumdarD, Deshpande A, Kumar R, et al. Medulloblastoma in childhood-King Edward Memorial hospital surgical experience and review: Comparative analysis of the case series of 365 patients. J Pediatr Neurosci. 2011;6(Suppl1):S78
- Nalita N, Ratanalert S, Kanjanapradit K, Chotsampancharoen T, Tunthanathip T. Survival and prognostic factors in pediatric patients with medulloblastoma in southern Thailand. J Pediatr Neurosci. 2018;13(2):150–7.
- Sirachainan N, Nuchprayoon I, Thanarattanakorn P, Pakakasama S, Lusawat A, Visudibhan A, et al. Outcome of medulloblastoma in children treated with reduced-dose radiation therapy plus adjuvant chemotherapy. J Clin Neurosci. 2011;18(4):515–59.
- Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, et al. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol. 2016;17(4):484–95
- Juraschka K, Taylor MD. Medulloblastoma in the age of molecular subgroups: a review. JNSPG 75th Anniversary Invited Review Article. J Neurosurg Pediatr. 2019;24(4):353–63
