Primary lymphoma presenting in the thyroid gland is rare, accounting for 2-8% of thyroid malignancies and 1-2% of extranodal malignancies. Mucosal lymphoid tissue-associated lymphoma (MALT) is one of the rare variants, first described by Isaacson and Wright in 1984. Primary MALT lymphoma of the thyroid gland accounts for 6-28% of tumors, closely related to chronic inflammatory or local autoimmune processes because thyroid tissue has no lymphatic organs. The coexistence between local inflammation and tumor formation causes many difficulties in disease diagnosis. Clinically, most patients are diagnosed at the age of over 60, with about 30% of patients having symptoms of local compression related to the tumor such as difficulty swallowing, shortness of breath, hoarseness. The standard treatment in MALT lymphoma is radiotherapy combined with chemotherapy; Surgery is valuable in diagnosis and symptom resolution. For asymptomatic patients regardless of stage who can be closely monitored, no treatment is required. In general, MALT lymphoma has a good prognosis, different from other histopathological types such as diffuse large B-cell lymphoma. Currently, there are not many reports on this clinical form, so we report 3 clinical cases, thereby drawing experience in the diagnosis and treatment of MALT lymphoma in the thyroid gland.

.